منابع مشابه
CARBOLINE INHIBITION OF ot - AMINO - ENKEPHALINASE
An enkephal in-degrading aminopeptidase (cz-aminoacyl-peptide hydrolase, EC 3.4.11.11) has been purified from human plasma and has been shown to be the pr inc ip le reasponsible for the transient half-l i fe of enkephalin in blood. An inh ib i to ry e f fec t of Bcarbol ines and of 3,4-d ihydro-B-carbol ines on this enzyme 'in vi tro' is reported. The best inhibitor is the 3-carboxyiic acid (K ...
متن کاملSequential Sonagashira and Larock Indole Synthesis Reactions in a General Strategy To Prepare Biologically Active β-Carboline-Containing Alkaloids
A general synthetic approach to β-carboline-containing alkaloids was developed. Two consecutive palladium-mediated processes, a Sonagashira coupling and a Larock indole annulation reaction, are central to the method. The scope of the approach was investigated and found to be amenable for constructing a variety of biologically significant natural products and also for preparing substituted analo...
متن کامل/?-Carboline Alkaloids from Ribes nigrum L
From Ribes nigrum L. two ß-carboline alkaloids (deshydroxymethyl flazin (1) and flazin methyl ether (2)) could be isolated in minute amounts. The structure elucidation is described. The two compounds are present in the freshly pressed juice, but they are also formed during storage of the juice by condensation of tryptophane with ascorbic acid or its degradation products. This could be shown by ...
متن کاملREACTIONS OF DIHYDROPYRIDINES WITH BENZYNE
Reactions of 1 ,Zdihydropyridines (la-c) and 1,4-dihydropyridines (2a-c) in the presence of benzyne (3) under thermal conditions, and in the case of (2c) under photochemical conditions, have been investigated. Benzyne acts as an oxidizing agent to convert dihydropyridine (la) and (2a) to the corresponding pyridine (4) or adds as a dienophile to (lb-c).
متن کاملA comparative molecular field analysis of cytotoxic beta-carboline analogs.
AIM To derive a model that could be used in drug design. METHODS Beta-carbolines are reported to have antitumor activities on cultured cancer cell lines. A comparative molecular field analysis (CoMFA) was undertaken to elucidate the correlation of cytotoxities and structural parameters of 16 beta-carboline analogs (1-16). The compound 12 was finally used as a template for the other compounds ...
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ژورنال
عنوان ژورنال: Spectroscopy
سال: 1997
ISSN: 0712-4813,1875-922X
DOI: 10.1155/1997/821241